Triethylamine → Ethyl 2-[12-hydroxy-2-oxadodecyl]acrylate

温度

0 °C

To a solution of 54.7 g trifluoromethanesulphonic anhydride in 210 ml dichloromethane a solution of 25 g (0.192 mol) α-hydroxyethylacrylate and 19.43 g (0.192 mol) triethylamine in 400 ml dichloromethane was added slowly, so that the temperature of the reaction mixture stays below 5° C. The solution was stirred for 45 min at 0° C. before it was added drop wise at room temperature to a solution of 60 g (0.344 mol) 1,10-decandiol in 400 ml dichloromethane. After the reaction mixture was stirred for 12 h at room temperature the solution was successively washed with 2×300 ml of an aqueous sodium carbonate solution (1 n) and 1×400 ml water. The organic layer was dried over magnesium sulphate and filtered. The raw product was prepurified by column chromatography on silica gel with ethyl acetate as eluens. After the raw product was stabilized with 113 mg BHT, it was finally purified by vacuum distillation (>150° C./0.028 mbar). This afforded 11.024 g (yield: 20%) of a clear, colourless product.

1. customstays below 5° C
2. stirringAfter the reaction mixture was stirred for 12 h at room temperature the solution
3. washwas successively washed with 2×300 ml of an aqueous sodium carbonate solution (1 n) and 1×400 ml water
4. dry with materialThe organic layer was dried over magnesium sulphate
5. filtrationfiltered
6. distillationwas finally purified by vacuum distillation (>150° C./0.028 mbar)

ORDレコード

ord-f3d8c120f6414dc4a6fcc8b82b9b5649

出典データセット

uspto-grants-2012_06

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US08198388B2