Trifluoroacetic acid → HCID 59909816、化合物

HRID 2183019ノート

反応式

HRID 2183019 の反応式
[Cl:1][C:2]1[CH:32]=[CH:31][C:5]([O:6][CH2:7][C:8]2[N:12]=[C:11]([C@H:13]([CH2:22][CH2:23][CH2:24][CH:25]3[CH2:30][CH2:29][CH2:28][CH2:27][CH2:26]3)[CH2:14][C:15]([O:17]C(C)(C)C)=[O:16])[O:10][N:9]=2)=[CH:4][CH:3]=1.FC(F)(F)C(O)=O>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([O:6][CH2:7][C:8]2[N:12]=[C:11]([C@H:13]([CH2:22][CH2:23][CH2:24][CH:25]3[CH2:30][CH2:29][CH2:28][CH2:27][CH2:26]3)[CH2:14][C:15]([OH:17])=[O:16])[O:10][N:9]=2)=[CH:31][CH:32]=1

参加物

3

反応物 2

HCID 6422Trifluoroacetic acidHCID 59909802HCID 59909802、化合物

生成物 1

HCID 59909816HCID 59909816、化合物収率 101%

実験手順

tert-Butyl (3R)-3-{3-[(4-chlorophenoxy)methyl]-1,2,4-oxadiazol-5-yl}-6-cyclohexylhexanoate (Preparation 56) (215 mg, 0.46 mmol) was treated with trifluoroacetic acid (5 ml) and the resulting mixture was stirred at room temperature under a nitrogen atmosphere for 4 hours. The solvent was removed under reduced pressure and the residue azeotroped from toluene to afford the title compound (189 mg).

後処理

  1. customThe solvent was removed under reduced pressure
  2. customthe residue azeotroped from toluene

出典と根拠

ORDレコード
ord-c3828588f2c946b9b5db644042361ec6
出典データセット
uspto-grants-2005_05
特許番号
US06897306B2

反応ノート

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