Sodium Carbonate → HCID 9943990、化合物

HRID 2183633ノート

反応式

HRID 2183633 の反応式
C(=O)([O-])[O-].[Na+].[Na+].Br.[S:8]1[C:12]([C:13]2[N:14]3[CH2:20][CH2:19][N:18]=[C:15]3[S:16][CH:17]=2)=[CH:11][C:10]2[CH:21]=[CH:22][CH:23]=[CH:24][C:9]1=2>ClCCl.O>[S:8]1[C:12]([C:13]2[N:14]3[CH2:20][CH2:19][N:18]=[C:15]3[S:16][CH:17]=2)=[CH:11][C:10]2[CH:21]=[CH:22][CH:23]=[CH:24][C:9]1=2

参加物

5

反応物 2

HCID 10340Sodium CarbonateHCID 22474170HCID 22474170、化合物

生成物 1

HCID 9943990HCID 9943990、化合物収率 90.5%

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 6344Dichloromethane溶媒

実験手順

Sodium carbonate (9.29 g) was added at 0° C. to a stirred suspension of 3-(benzo[b]thiophen-2-yl)-5,6-dihydroimidazo[2,1-b]thiazole hydrobromide (19.0 g) in a mixture of dichloromethane (300 ml) and water (300 ml). The mixture was stirred at ambient temperature for 3 hours, then the organic phase was separated, washed with water (200 ml) and saturated aqueous sodium chloride solution (200 ml), dried (Na2SO4) and the solvents were removed in vacuo to give 3-(benzo[b]thiophen-2-yl)-5,6-dihydroimidazo[2,1-b]thiazole as a brown solid (13.1 g) which was used without further purification.

後処理

  1. customthe organic phase was separated
  2. washwashed with water (200 ml) and saturated aqueous sodium chloride solution (200 ml)
  3. dry with materialdried (Na2SO4)
  4. customthe solvents were removed in vacuo

出典と根拠

ORDレコード
ord-6862eca620ff44419eb52980ee99c1a7
出典データセット
uspto-grants-2005_05
特許番号
US06900216B2

反応ノート

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