Water → HCID 9835604、化合物

HRID 2183635ノート

反応式

HRID 2183635 の反応式
[BH4-].[Na+].[S:3]1[C:7]([C:8]2[N:9]3[CH2:17][CH2:16][N:15]=[C:10]3[S:11][C:12]=2[CH:13]=[O:14])=[CH:6][C:5]2[CH:18]=[CH:19][CH:20]=[CH:21][C:4]1=2.O>CO>[S:3]1[C:7]([C:8]2[N:9]3[CH2:17][CH2:16][N:15]=[C:10]3[S:11][C:12]=2[CH2:13][OH:14])=[CH:6][C:5]2[CH:18]=[CH:19][CH:20]=[CH:21][C:4]1=2

参加物

5

反応物 3

HCID 962WaterHCID 4311764Sodium borohydrideHCID 22473695HCID 22473695、化合物

生成物 1

HCID 9835604HCID 9835604、化合物収率 37.4%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

Sodium borohydride (0.144 g) was added in portions over 10 minutes to a stirred suspension of 3-(benzo[b]thiophen-2-yl)-5,6-dihydroimidazo[2,1-b]-thiazole-2-carboxaldehyde (0.73 g) in methanol (20 ml), then the mixture was stirred at ambient temperature for 2 hours and allowed to stand at ambient temperature for 18 hours. Water (35 ml) was added and the mixture was stirred at ambient temperature for 10 minutes. The resulting solid was collected by filtration and dissolved in a 9:1 mixture of dichloromethane and ethanol (50 ml). The solution was dried (Na2SO4) and the solvents were removed in vacuo to give [3-(benzo[b]thiophen-2-yl)-5,6-dihydroimidazo[2,1-b]thiazol-2-yl]methanol (0.275 g) as a brown solid, m.p. 138-140° C.

後処理

  1. waitto stand at ambient temperature for 18 hours
  2. stirringthe mixture was stirred at ambient temperature for 10 minutes
  3. filtrationThe resulting solid was collected by filtration
  4. dissolutiondissolved in a 9:1 mixture of dichloromethane and ethanol (50 ml)
  5. dry with materialThe solution was dried (Na2SO4)
  6. customthe solvents were removed in vacuo

出典と根拠

ORDレコード
ord-7733cb4193ef424eb88d2cc0f11bc047
出典データセット
uspto-grants-2005_05
特許番号
US06900216B2

反応ノート

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