Hydrochloric Acid → 4-Chlorobenzo(b)thiophene-2-carboxylic Acid
反応式
[Cl:1][C:2]1[C:10]2[CH:9]=[C:8]([C:11]([O:13]C)=[O:12])[S:7][C:6]=2[CH:5]=[CH:4][CH:3]=1.[OH-].[Na+].Cl>O>[Cl:1][C:2]1[C:10]2[CH:9]=[C:8]([C:11]([OH:13])=[O:12])[S:7][C:6]=2[CH:5]=[CH:4][CH:3]=1参加物
5
反応条件
- 温度
- 95 °C
実験手順
A mixture of methyl 4-chlorobenzo[b]thiophene-2-carboxylate (20 g), 5M aqueous sodium hydroxide solution (100 ml) and water (300 ml) was heated at 95° C. for 5 hours then poured into a mixture of concentrated hydrochloric acid (180 ml) and water (2000 ml) and stirred at ambient temperature for 2 hours. The resulting solid was collected by filtration, washed with water (3×500 ml), and dried in vacuo at 60° C. to give 4-chlorobenzo[b]thiophene-2-carboxylic acid (21.0 g) as an off-white solid, m.p. 246-248° C.
後処理
- filtrationThe resulting solid was collected by filtration
- washwashed with water (3×500 ml)
- customdried in vacuo at 60° C.
出典と根拠
- ORDレコード
- ord-46afb15436ed4d5d881dc0d1f26ecf81
- 出典データセット
- uspto-grants-2005_05
- 特許番号
- US06900216B2
反応ノート
読み込み中…