Imidazole → HCID 10222227、化合物
反応式
Br[CH2:2][C:3]1[CH:8]=[CH:7][N:6]2[C:9]([C:12]3[CH:13]=[CH:14][C:15]([F:26])=[C:16]([C:18]4[C:19]([C:24]#[N:25])=[CH:20][CH:21]=[CH:22][CH:23]=4)[CH:17]=3)=[CH:10][N:11]=[C:5]2[N:4]=1.[Na].[NH:28]1[CH:32]=[CH:31][N:30]=[CH:29]1>>[F:26][C:15]1[CH:14]=[CH:13][C:12]([C:9]2[N:6]3[CH:7]=[CH:8][C:3]([CH2:2][N:28]4[CH:32]=[CH:31][N:30]=[CH:29]4)=[N:4][C:5]3=[N:11][CH:10]=2)=[CH:17][C:16]=1[C:18]1[C:19]([C:24]#[N:25])=[CH:20][CH:21]=[CH:22][CH:23]=1参加物
4
実験手順
5′-(7-Bromomethylimidazo[1,2-α]pyrimidin-3-yl)-2′-fluorobiphenyl-2-carbonitrile was reacted with the sodium salt of imidazole as described in Example 34 to give 2′-fluoro-5′-[7-(imidazol-1-ylmethyl)imidazo[1,2-α]pyrimidin-3-yl]biphenyl-2-carbonitrile: δH (360 MHz, CDCl3) 5.33 (2H, s), 6.62 (1H, d, J 7), 7.05 (1H, s), 7.15 (1H, s), 7.38-7.43 (1H, m), 7.52-7.73 (6H, m), 7.83 (1H, d, J 7), 7.92 (1H, s), 8.80 (1H, s); m/z (ES+) 395 (M++H).
出典と根拠
- ORDレコード
- ord-f42da70d0edc4f81875858223858d346
- 出典データセット
- uspto-grants-2005_05
- DOI