化工社化工社 化学情報印刷レポート · 研究参考用
Citric Acid → N-Methyl-N-phenyl-glycine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Citric Acid | HCID 311 | — |
| 反応物 | Sodium Hydroxide | HCID 14798 | — |
| 反応物 | (Methyl-phenyl-amino)-acetic acid ethyl ester | HCID 265936 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 生成物 | N-Methyl-N-phenyl-glycine | HCID 420843 | — |
反応手順
The product of step 1 (1.1 g, 5.6 mmol) was dissolved in methanol (50 mL) and 1M NaOH (17 mL) added. Allow reaction mixture to stir at ambient temperature over 18 hours. 10% Citric acid solution was added until a pH=4 was reached. Extract several times with EtOAc. The organic layer was washed several times with brine, dried (Na2SO4), filtered, and concentrated affording a quantitative yield of the title compound as a yellow oil. MS (ES+) m/z 166 (MH+).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06900244B2 |
| 出典データセット | uspto-grants-2005_05 |
| ORD ID | ord-03fbe0f0d40340a7bc7bf134029aebc9 |
| 出典メモ | uspto-grants-2005_05 |