Lithium Hydroxide → 2-(Methylthio)pyrimidine-5-carboxylic acid

HRID 2184226ノート

反応式

HRID 2184226 の反応式
[CH3:1][S:2][C:3]1[N:8]=[CH:7][C:6]([C:9]([O:11]CC)=[O:10])=[CH:5][N:4]=1.[Li+].[OH-]>O1CCOCC1>[CH3:1][S:2][C:3]1[N:8]=[CH:7][C:6]([C:9]([OH:11])=[O:10])=[CH:5][N:4]=1

参加物

4

反応物 2

HCID 3939Lithium HydroxideHCID 10442716Ethyl 2-(methylthio)pyrimidine-5-carboxylate

生成物 1

HCID 36317942-(Methylthio)pyrimidine-5-carboxylic acid

試薬・触媒・溶媒 1

HCID 312751,4-Dioxane溶媒

実験手順

1 Eq. of 2-methylthio-5-ethoxycarbonylpyrimidine were dissolved in dioxane and, after addition of 2 eq. of 2N LiOH, stirred overnight. The solvent was then removed under reduced pressure, and the residue was dissolved in EtOH. After addition of a stoichiometric amount of ethereal HCl, the solution was again evaporated to dryness. Water which was still present was removed by azeotropic drying with toluene once. (b) 2-Methylthio-5-hydroxymethylpyrimidine

後処理

  1. customThe solvent was then removed under reduced pressure
  2. dissolutionthe residue was dissolved in EtOH
  3. additionAfter addition of a stoichiometric amount of ethereal HCl
  4. customthe solution was again evaporated to dryness
  5. customWater which was still present was removed
  6. dry with materialby azeotropic drying with toluene once

出典と根拠

ORDレコード
ord-a35e869f54494accbfc7339c91fba265
出典データセット
uspto-grants-2005_05
特許番号
US06900319B2

反応ノート

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