Nitric Acid → 4-Mesyl-2-nitrotoluene

HRID 21844

反応式

HRID 21844 の反応式
[CH3:1][S:2]([C:5]1[CH:10]=[CH:9][C:8]([CH3:11])=[CH:7][CH:6]=1)(=[O:4])=[O:3].[N+:12]([O-])([OH:14])=[O:13]>S(=O)(=O)(O)O>[CH3:1][S:2]([C:5]1[CH:10]=[CH:9][C:8]([CH3:11])=[C:7]([N+:12]([O-:14])=[O:13])[CH:6]=1)(=[O:3])=[O:4]

参加物

4

反応物 2

HCID 944Nitric AcidHCID 18521p-Tolyl methyl sulfone

生成物 1

HCID 6871254-Mesyl-2-nitrotoluene

試薬・触媒・溶媒 1

HCID 1118Sulfuric Acid溶媒2 回

反応条件

温度
10 °C

実験手順

68 g of 4-methylsulfonyltoluene in 400 ml of concentrated sulfuric acid were admixed at 0°-10° C. with a mixture of 80 ml of concentrated sulfuric acid and 31 ml of 65% strength by weight nitric acid. The reaction mixture was stirred at 10° C. for 2 hours and at room temperature for a further 2 hours. It was then poured onto about 1 kg of ice, and the solids were filtered off with suction, washed with water and dried at 50° C. under reduced pressure, to leave 85 g of 4-methylsulfonyl-2-nitrotoluene (melting point 112°-115° C.).

後処理

  1. filtrationthe solids were filtered off with suction
  2. washwashed with water
  3. customdried at 50° C. under reduced pressure

出典と根拠

ORDレコード
ord-6b452798bf2a4573bf046125764f2e48
出典データセット
uspto-grants-1995_06
特許番号
US05424481

関連ノート

読み込み中…