Hydrazine → 1H-Pyrazolo(4,3-b)pyridine

HRID 218464

反応式

HRID 218464 の反応式
F[C:2]1[C:3]([CH:8]=O)=[N:4][CH:5]=[CH:6][CH:7]=1.[NH2:10][NH2:11]>O>[NH:10]1[C:2]2[C:3](=[N:4][CH:5]=[CH:6][CH:7]=2)[CH:8]=[N:11]1

参加物

4

反応物 2

HCID 9321HydrazineHCID 113440173-Fluoro-2-pyridinecarboxaldehyde

生成物 1

HCID 216436531H-Pyrazolo(4,3-b)pyridine収率 60.4%

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

A mixture of 3-fluoro-2-pyridinecarboxaldehyde (4 g, 32 mmol) and hydrazine (20.5 g) was kept at 115° C. for 7 hr, then cooled to rt. The reaction mixture was diluted with water and extracted with EtOAc. The organic phases were combined, washed with brine, and dried. Concentration followed by flash chromatography afforded 1H-pyrazolo[4,3-b]pyridine (2.3 g, 60.4%).

後処理

  1. extractionextracted with EtOAc
  2. washwashed with brine
  3. customdried
  4. concentrationConcentration

出典と根拠

ORDレコード
ord-2a2bc17e86064d979af9365c6fef2b04
出典データセット
uspto-grants-2012_06
特許番号
US08198456B2

関連ノート

読み込み中…