2-Methoxyethylamine → HCID 22457966、化合物
反応式
CO[C:3]([C:5]1[CH:10]=[N:9][C:8]([C:11]([O:13]C)=O)=[CH:7][N:6]=1)=[O:4].[CH3:15][O:16][CH2:17][CH2:18][NH2:19]>C(O)C>[CH3:15][O:16][CH2:17][CH2:18][NH:19][C:11]([C:8]1[CH:7]=[N:6][C:5]([C:3]([NH:19][CH2:18][CH2:17][O:16][CH3:15])=[O:4])=[CH:10][N:9]=1)=[O:13]参加物
4
反応条件
- 温度
- 20 °C
実験手順
A solution of 500 mg of 2,5-dimethoxycarbonylpyrazine and 0.430 cm3 of 2-methoxyethylamine in 3 cm3 of ethanol is heated at a temperature in the region of the reflux temperature for 5 hours. The reaction mixture is cooled to a temperature of 20° C. and the white solid formed is then filtered off and washed with twice 5 cm3 of ethanol. 150 mg of N,N′-bis-(2-methoxyethyl)pyrazine-2,5-dicarboxamide are thus obtained in the form of a white solid melting at 165° C. [1H NMR spectrum (300 MHz, (CD3)2SO-d6, δ in ppm): 3.29 (s, 6H: 2×OCH3); 3.51 (mt, 8H: 2×NCH2CH2O); 8.99 (mt, 2H: 2×CONH); 9.22 (s, 2H: ═CH at 3 and ═CH at 6)].