Nitric Acid → 3-nitro-9-isopropyl-9H-carbazole

HRID 2184930ノート

反応式

HRID 2184930 の反応式
[CH:1]([N:4]1[C:16]2[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=2[C:10]2[C:5]1=[CH:6][CH:7]=[CH:8][CH:9]=2)([CH3:3])[CH3:2].[N+:17]([O-])([OH:19])=[O:18].O>CC(O)=O>[CH:1]([N:4]1[C:16]2[CH:15]=[CH:14][C:13]([N+:17]([O-:19])=[O:18])=[CH:12][C:11]=2[C:10]2[C:5]1=[CH:6][CH:7]=[CH:8][CH:9]=2)([CH3:3])[CH3:2]

参加物

5

反応物 3

HCID 944Nitric AcidHCID 962WaterHCID 738739H-Carbazole, 9-(1-methylethyl)-

生成物 1

HCID 6174713-nitro-9-isopropyl-9H-carbazole収率 87%

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒2 回

実験手順

A solution of 9-Isopropyl-9H-carbazole (Acros, 1.5 9, 7.2 mmol) in AcOH (50 ml) was treated dropwise with a solution of nitric acid (3.35 ml) in AcOH (10 mL) over 30 minutes. When the reaction was complete the mixture was poured into water and stirred for 15 minutes, then the solid filtered and washed with Et2O to afford the desired product as a solid (1.6 g, 87%).

後処理

  1. filtrationthe solid filtered
  2. washwashed with Et2O

出典と根拠

ORDレコード
ord-fc95bb89ea3c446d8d28849dd4eddc91
出典データセット
uspto-grants-2002_06
特許番号
US06399631B1

反応ノート

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