HCID 59586742、化合物 → HCID 59586756、化合物
反応式
C(O[CH:5]([C:8]1[C:9]([F:14])=[N:10][CH:11]=[CH:12][CH:13]=1)[CH2:6][CH3:7])(=O)C.[H][H]>C(O)C.[Pd]>[CH2:5]([C:8]1[C:9]([F:14])=[N:10][CH:11]=[CH:12][CH:13]=1)[CH2:6][CH3:7]参加物
5
実験手順
3.50 g (17.7 mmol) of the product from example 49A are dissolved in 30 ml of ethanol and admixed with 2.00 g of 10% palladium on activated carbon. Hydrogenation is effected overnight in a hydrogen atmosphere under standard pressure. The mixture is filtered with suction, washed with ethanol and concentrated cautiously under reduced pressure. This affords 1.9 g of approx. 89% pure product (69% of theory), which is converted further without purification.
後処理
- filtrationThe mixture is filtered with suction
- washwashed with ethanol
- concentrationconcentrated cautiously under reduced pressure
- customThis affords 1.9 g of approx. 89% pure product (69% of theory), which is converted further without purification
出典と根拠
- ORDレコード
- ord-95be74c586c74e8ea53d18b7c3ab4a50
- 出典データセット
- uspto-grants-2012_06
- 特許番号
- US08198267B2
反応ノート
読み込み中…