Acetic Acid → N-tert-Butoxycarbonyl-trans-4-(N,N-Dimethylglycylamino)-L-Proline

HRID 2185421ノート

反応式

HRID 2185421 の反応式
O.[OH-].[Li+].C[O:5][C:6](=[O:26])[C@@H:7]1[CH2:11][C@@H:10]([NH:12][C:13](=[O:18])[CH2:14][N:15]([CH3:17])[CH3:16])[CH2:9][N:8]1[C:19]([O:21][C:22]([CH3:25])([CH3:24])[CH3:23])=[O:20].CO.C(O)(=O)C>O.O1CCCC1>[C:22]([O:21][C:19]([N:8]1[CH2:9][C@H:10]([NH:12][C:13](=[O:18])[CH2:14][N:15]([CH3:16])[CH3:17])[CH2:11][C@H:7]1[C:6]([OH:26])=[O:5])=[O:20])([CH3:25])([CH3:24])[CH3:23]

参加物

7

反応物 4

HCID 176Acetic AcidHCID 887MethanolHCID 168937Lithium hydroxide, monohydrateHCID 21341540N-tert-Butoxycarbonyl-trans-4-(N,N-Dimethylglycylamino)-L-Proline Methyl Ester

生成物 1

HCID 21341539N-tert-Butoxycarbonyl-trans-4-(N,N-Dimethylglycylamino)-L-Proline

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 8028Tetrahydrofuran溶媒

実験手順

A solution of lithium hydroxide monohydrate (40 mg) in water (1 mL) was added to a solution of N-tert-butoxycarbonyl-trans-4-(N,N-dimethylglycylamino)-L-proline methyl ester (A, 264 mg) in tetrahydrofuran (3 mL)-methanol (1 mL) at 0° C. After stirring at room temperature for 4 hr, acetic acid (55 L) was added to the reaction mixture at 0° C. The resulting solution was evaporated in vacuo to afford the crude title compound, which is used in the subsequent step.

後処理

  1. customThe resulting solution was evaporated in vacuo

出典と根拠

ORDレコード
ord-543747a9b3074c3a9fc17da6471de2aa
出典データセット
uspto-grants-2002_06
特許番号
US06399629B1

反応ノート

読み込み中…