Trifluoroacetic acid → 4-(3,5-Dichlorophenoxy)piperidine

HRID 2185480ノート

反応式

HRID 2185480 の反応式
FC(F)(F)C(O)=O.C(OC([N:15]1[CH2:20][CH2:19][CH:18]([O:21][C:22]2[CH:27]=[C:26]([Cl:28])[CH:25]=[C:24]([Cl:29])[CH:23]=2)[CH2:17][CH2:16]1)=O)(C)(C)C>ClCCl>[Cl:29][C:24]1[CH:23]=[C:22]([CH:27]=[C:26]([Cl:28])[CH:25]=1)[O:21][CH:18]1[CH2:19][CH2:20][NH:15][CH2:16][CH2:17]1

参加物

4

反応物 2

HCID 6422Trifluoroacetic acidHCID 22458487n-Tert-butoxycarbonyl-4-(3,5-dichlorophenoxy)piperidine

生成物 1

HCID 224584124-(3,5-Dichlorophenoxy)piperidine

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

Trifluoroacetic acid (10 mL) was added to a solution of N-tert-butoxycarbonyl-4-(3,5-dichlorophenoxy)piperidine (A, 815 mg) in dichloromethane (20 mL) at room temperature. After stirring at room temperature for 30 min, the reaction mixture was evaporated in vacuo. The residue was partitioned between chloroform and saturated sodium hydrogen carbonate. The organic layer was dried over anhydrous sodium sulfate and then concentrated in vacuo to give the title compound, which was washed with hexane and used in the next reaction without further purification.

後処理

  1. customthe reaction mixture was evaporated in vacuo
  2. customThe residue was partitioned between chloroform and saturated sodium hydrogen carbonate
  3. dry with materialThe organic layer was dried over anhydrous sodium sulfate
  4. concentrationconcentrated in vacuo

出典と根拠

ORDレコード
ord-0e938db6a8f0498b9f01c9ccc8bba9cc
出典データセット
uspto-grants-2002_06
特許番号
US06399629B1

反応ノート

読み込み中…