1,2,3,4-Tetrahydro-1-naphthoic acid → N-(6-isopropylpyridin-3-yl)-1,2,3,4-tetrahydronaphthalene-1-carboxamide

HRID 218549

反応式

HRID 218549 の反応式
[CH:1]1([C:11]([OH:13])=O)[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH2:4][CH2:3][CH2:2]1.[NH2:14][C:15]1[CH:16]=[CH:17][C:18]([CH:21]([CH3:23])[CH3:22])=[N:19][CH:20]=1>>[CH:21]([C:18]1[N:19]=[CH:20][C:15]([NH:14][C:11]([CH:1]2[C:10]3[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=3)[CH2:4][CH2:3][CH2:2]2)=[O:13])=[CH:16][CH:17]=1)([CH3:23])[CH3:22]

参加物

3

反応物 2

HCID 125981461,2,3,4-Tetrahydro-1-naphthoic acidHCID 178542886-(Propan-2-yl)pyridin-3-amine

生成物 1

HCID 17854426N-(6-isopropylpyridin-3-yl)-1,2,3,4-tetrahydronaphthalene-1-carboxamide収率 86.4%

実験手順

By the reaction and treatment in the same manner as in Preparation Example 11 using 1,2,3,4-tetrahydronaphthalene-1-carboxylic acid (1.51 g) and 5-amino-2-isopropylpyridine (1.17 g) as starting materials, N-(6-isopropylpyridin-3-yl)-1,2,3,4-tetrahydronaphthalene-1-carboxamide (2.18 g) was obtained. melting point: 155.7° C.

後処理

  1. customBy the reaction and treatment in the same manner

出典と根拠

ORDレコード
ord-059f4241356a4b3eacb0ba0fe5a8db36
出典データセット
uspto-grants-2012_06
特許番号
US08198454B2

関連ノート

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