Oxalyl chloride → 3-Cyano-5,6,7,8-tetrahydronaphthalene-1-carbonyl chloride
反応式
[C:1]([C:3]1[CH:4]=[C:5]([C:13]([OH:15])=O)[C:6]2[CH2:7][CH2:8][CH2:9][CH2:10][C:11]=2[CH:12]=1)#[N:2].C(Cl)(=O)C([Cl:19])=O>C(Cl)Cl.CN(C=O)C>[C:1]([C:3]1[CH:4]=[C:5]([C:13]([Cl:19])=[O:15])[C:6]2[CH2:7][CH2:8][CH2:9][CH2:10][C:11]=2[CH:12]=1)#[N:2]参加物
5
実験手順
To a solution of 3-cyano-5,6,7,8-tetrahydro-1-naphthalenecarboxylic acid (0.207 g, 1.03 mmol) in DCM (5 mL) was added oxalyl chloride (0.112 mL, 1.29 mmol) and 1 drop of DMF. The mixture was stirred at room temperature for 2 h., the solvent was removed in vacuo and the 3-cyano-5,6,7,8-tetrahydro-1-naphthalenecarbonyl chloride was used without purification.
後処理
- customthe solvent was removed in vacuo
- customthe 3-cyano-5,6,7,8-tetrahydro-1-naphthalenecarbonyl chloride was used without purification
出典と根拠
- ORDレコード
- ord-055cebf526db482ba19956c73b9b5f72
- 出典データセット
- uspto-grants-2002_06
- 特許番号
- US06403601B1
反応ノート
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