Hydrogen Bromide → 1-(5-Chloro-2-hydroxyphenyl)piperazine dihydrobromide
反応式
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([O:14]C)=[C:6]([N:8]2[CH2:13][CH2:12][NH:11][CH2:10][CH2:9]2)[CH:7]=1.[BrH:16]>>[BrH:16].[BrH:16].[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([OH:14])=[C:6]([N:8]2[CH2:9][CH2:10][NH:11][CH2:12][CH2:13]2)[CH:7]=1参加物
3
実験手順
A suspension of 5.5 g of 1-(5-chloro-2-methoxyphenyl)piperazine in 40 mL of 62% hydrobromic acid was stirred at reflux for 30 hours. After cooling to room temperature the mixture was filtered by suction and the solid was washed on the funnel with acetone affording 6.02 g of the title compound. M.p.>270° C. (ethanol).
後処理
- temperatureat reflux for 30 hours
- filtrationwas filtered by suction
- washthe solid was washed on the funnel with acetone affording 6.02 g of the title compound
出典と根拠
- ORDレコード
- ord-b5b8d4754fe64f44b7a713d3becbb443
- 出典データセット
- uspto-grants-2002_06
- 特許番号
- US06403594B1
反応ノート
読み込み中…