Sodium Carbonate → HCID 70193430、化合物

HRID 2186428ノート

反応式

HRID 2186428 の反応式
[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([C:7]2[N:8]=[CH:9][N:10]([CH:12]([CH3:16])[CH2:13][CH:14]=O)[CH:11]=2)[CH:2]=1.[NH:17]([C:19]([O:21][C:22]([CH3:25])([CH3:24])[CH3:23])=[O:20])[NH2:18].C(=O)([O-])[O-].[Na+].[Na+]>CC(O)=O.O.CCOC(C)=O>[CH3:23][C:22]([O:21][C:19]([NH:17][NH:18][CH2:14][CH2:13][C@H:12]([N:10]1[CH:11]=[C:7]([C:3]2[CH:2]=[N:1][CH:6]=[CH:5][CH:4]=2)[N:8]=[CH:9]1)[CH3:16])=[O:20])([CH3:25])[CH3:24]

参加物

7

反応物 3

HCID 10340Sodium CarbonateHCID 70091tert-Butyl carbazateHCID 18759767β-Methyl-4-(3-pyridinyl)-1H-imidazole-1-propanal

生成物 1

HCID 70193430HCID 70193430、化合物

試薬・触媒・溶媒 3

HCID 176Acetic Acid溶媒HCID 962Water溶媒HCID 8857Ethyl Acetate溶媒

実験手順

(R/S)-3-(4-pyridin-3-yl-imidazol-1-yl)-butan-1-al (11) (1 mmol) is dissolved in 10 mL HOAc and t-butyl hydrazinecarboxylate (1.1 mmol) is added. After 1 h, NaHB(OAc)3 (5 mmol) is added at 25° C. After 2 h, the reaction is poured into sodium carbonate in water and EtOAc. The water layer is removed, the organics are washed with brine, and dried over sodium sulfate. The solvent is removed in vacuo to leave the product (32).

後処理

  1. waitAfter 2 h
  2. customThe water layer is removed
  3. washthe organics are washed with brine
  4. dry with materialdried over sodium sulfate
  5. customThe solvent is removed in vacuo

出典と根拠

ORDレコード
ord-ecf2ad3b1cd74d89a09ecf67779636c5
出典データセット
uspto-grants-2002_06
特許番号
US06403776B1

反応ノート

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