Azetidine → 2-(Azetidin-1-yl)7-bromo-4-methoxybenzooxazole

反応式

[Br:1][C:2]1[C:10]2[O:9][C:8](SC)=[N:7][C:6]=2[C:5]([O:13][CH3:14])=[CH:4][CH:3]=1.[NH:15]1[CH2:18][CH2:17][CH2:16]1>>[N:15]1([C:8]2[O:9][C:10]3[C:2]([Br:1])=[CH:3][CH:4]=[C:5]([O:13][CH3:14])[C:6]=3[N:7]=2)[CH2:18][CH2:17][CH2:16]1

参加物

反応物 2

HCID 10422Azetidine

HCID 224566517-Bromo-4-methoxy-2-methylsulfanylbenzooxazole

生成物 1

HCID 224566552-(Azetidin-1-yl)7-bromo-4-methoxybenzooxazole収率 59.5%

実験手順

Starting from 7-bromo-4-methoxy-2-methylsulfanylbenzooxazole (4.8 g) and azetidine (1.0 g). Purification by chromatography on silica eluting with 50% ethyl acetate in heptane afforded the title compound as a pink solid (2.95 g).

後処理

customPurification by chromatography on silica eluting with 50% ethyl acetate in heptane

出典と根拠

ORDレコード: ord-e0f7a3c9d3d94720bae8ae7923006e2e
出典データセット: uspto-grants-2002_06
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US06403791B1

反応ノート

読み込み中…

参加物