5-Amino-1-methyl-1H-pyrazole-4-carbonitrile → 4-Difluoromethoxy-2-(piperidin-1-yl)-benzooxazole-7-carboxylic acid (4-cyano-2-methyl-2H-pyrazol-3-yl)-amide

HRID 2186467

反応式

HRID 2186467 の反応式
[N+](C1C=CC(O[C:11]([C:13]2[C:21]3[O:20][C:19]([N:22]4[CH2:27][CH2:26][CH2:25][CH2:24][CH2:23]4)=[N:18][C:17]=3[C:16]([O:28][CH:29]([F:31])[F:30])=[CH:15][CH:14]=2)=[O:12])=CC=1)([O-])=O.[NH2:32][C:33]1[N:37]([CH3:38])[N:36]=[CH:35][C:34]=1[C:39]#[N:40]>>[C:39]([C:34]1[CH:35]=[N:36][N:37]([CH3:38])[C:33]=1[NH:32][C:11]([C:13]1[C:21]2[O:20][C:19]([N:22]3[CH2:27][CH2:26][CH2:25][CH2:24][CH2:23]3)=[N:18][C:17]=2[C:16]([O:28][CH:29]([F:30])[F:31])=[CH:15][CH:14]=1)=[O:12])#[N:40]

参加物

3

反応物 2

HCID 2197405-Amino-1-methyl-1H-pyrazole-4-carbonitrileHCID 698385344-Difluoromethoxy-2-(piperidin-1-yl)-benzooxazole-7-carboxylic acid 4-nitro-phenyl ester

生成物 1

HCID 102019834-Difluoromethoxy-2-(piperidin-1-yl)-benzooxazole-7-carboxylic acid (4-cyano-2-methyl-2H-pyrazol-3-yl)-amide収率 14.9%

実験手順

Starting from 4-difluoromethoxy-2-(piperidin-1-yl)-benzooxazole-7-carboxylic acid 4-nitro-phenyl ester (0.35 g) and 5-amino-1-methyl-1H-pyrazole-4-carbonitrile (0.197 g). Purification by column chromatography on silica eluting with 50% ethyl acetate in heptane afforded the title compound as a white solid (50 mg).

後処理

  1. customPurification by column chromatography on silica eluting with 50% ethyl acetate in heptane

出典と根拠

ORDレコード
ord-c96463d8c8374bc2adb91e3d0af30960
出典データセット
uspto-grants-2002_06
特許番号
US06403791B1

関連ノート

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