tert-Butanol → 1-Benzylazetidine-2-carboxylic acid
反応式
C[O:2][C:3]([CH:5]1[CH2:8][CH2:7][N:6]1[CH2:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)=[O:4].C(O)(C)(C)C>O>[CH2:9]([N:6]1[CH2:7][CH2:8][CH:5]1[C:3]([OH:4])=[O:2])[C:10]1[CH:11]=[CH:12][CH:13]=[CH:14][CH:15]=1参加物
4
反応条件
- 温度
- 40 °C
実験手順
N-Benzylazetidine-2-carboxylic acid methyl ester (1 g), 90 mg of t-butanol, 90 mg of water were mixed at 20 to 25° C. and 180 mg of Chirazyme L-2 were mixed and the resulting solution was heated to 40° C. and stirred for 2 hours. Thereafter 1 ml of water was added thereto and washed with 4 ml of t-butyl methyl ether thrice to obtain an aqueous solution of optically active N-benzylazetidine-2-carboxylic acid. Combined organic phase gave a solution of N-Benzylazetidine-2-carboxylic acid methyl ester.
後処理
- additionwere mixed
- washwashed with 4 ml of t-butyl methyl ether thrice
出典と根拠
- ORDレコード
- ord-7fa33dbc2e9d4b678993183701afdcbc
- 出典データセット
- uspto-grants-2002_06
- 特許番号
- US06410279B1
反応ノート
読み込み中…