Sodium Hydroxide → HCID 18476074、化合物
反応式
FC1C=CC([CH:8]([NH:15][C:16]2[CH:25]=[CH:24][C:19]([C:20]([O:22]C)=[O:21])=[C:18]([C:26]3[CH:31]=[CH:30][C:29]([F:32])=[CH:28][CH:27]=3)[CH:17]=2)[CH2:9][N:10]2[CH:14]=[CH:13][N:12]=[CH:11]2)=CC=1.[OH-].[Na+]>CO>[F:32][C:29]1[CH:30]=[CH:31][C:26]([N:15]([CH2:8][CH2:9][N:10]2[CH:14]=[CH:13][N:12]=[CH:11]2)[C:16]2[CH:25]=[CH:24][C:19]([C:20]([OH:22])=[O:21])=[C:18]([C:26]3[CH:27]=[CH:28][C:29]([F:32])=[CH:30][CH:31]=3)[CH:17]=2)=[CH:27][CH:28]=1参加物
4
実験手順
Methyl 4-[1-(4-fluorophenyl)-2-(imidazol-1-yl)ethylamino]-2-(4-fluorophenyl)benzoate (4.36 g; 10 mmol) in methanol (100 ml) was treated with 2N aqueous sodium hydroxide solution (20 ml; 40 mmol) at reflux for 24 hours. After evaporation of the methanol, the residue was taken up in water, the pH adjusted to 4.5 with HCl 2N. The resulting precipitate was filtered, washed with water and pentane to give 4-[-(4-fluorophenyl)-2-(imidazol-1-yl)ethylamino]-2-(4-fluorophenyl)benzoic acid as a solid (4 g; 95%).