Sodium Carbonate → 1h-Indole-3-acetic acid,2-phenyl-,ethyl ester

To a solution of 2.0 g (7.1 mmol) of ethyl (2-bromoindol-3-yl)acetate in 40 ml of dioxane was added under argon 1.2 g (0.11 mmol) of Pd(PPh3)4 and 13.3 ml of 2.0 M sodium carbonate. After stirring at room temperature for ca. 15 min, 1.3 g (11 mmol) of benzeneboronic acid was added, and the mixture was heated at 80° C. under argon overnight. The mixture was cooled to room temperature and solids were removed by filtration. The filtrate was concentrated and chromatographed on silica gel with toluene as an eluent to yield 1.6 g (81%) of the 2-phenyl indole as a yellow crystalline solid.

1. temperaturethe mixture was heated at 80° C. under argon overnight
2. temperatureThe mixture was cooled to room temperature
3. customsolids were removed by filtration
4. concentrationThe filtrate was concentrated
5. customchromatographed on silica gel with toluene as an eluent

ORDレコード

ord-fd2b2434d51e4ab8bdf44da49d132eb7

出典データセット

uspto-grants-2002_06

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US06410562B1