Thionyl Chloride → HCID 18476333、化合物

反応式

[F:1][C:2]([F:20])([F:19])[C:3]1[NH:4][C:5]2[C:10]([C:11]=1[C:12](O)=[O:13])=[CH:9][C:8]([C:15]([F:18])([F:17])[F:16])=[CH:7][CH:6]=2.S(Cl)([Cl:23])=O>>[F:1][C:2]([F:20])([F:19])[C:3]1[NH:4][C:5]2[C:10]([C:11]=1[C:12]([Cl:23])=[O:13])=[CH:9][C:8]([C:15]([F:18])([F:17])[F:16])=[CH:7][CH:6]=2

参加物

反応物 2

HCID 24386Thionyl Chloride

HCID 17840233HCID 17840233、化合物

生成物 1

HCID 18476333HCID 18476333、化合物

反応条件

温度: 70 °C

実験手順

A mixture of 500 mg (1.68 mmol) of the indolecarboxylic acid from Step 4 and 20 ml of thionyl chloride was heated for 3 at 70° C. The excess of thionyl chloride was removed under reduced pressure and the remaining crude acid chloride was dissolved in 30 ml of dry dichloromethane. This solution was used in the next step.

後処理

customThe excess of thionyl chloride was removed under reduced pressure
dissolutionthe remaining crude acid chloride was dissolved in 30 ml of dry dichloromethane

出典と根拠

ORDレコード: ord-4d058dc91015445e8e9229bb609a49e8
出典データセット: uspto-grants-2002_06
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US06410562B1

反応ノート

読み込み中…

参加物