Hydroxyamine hydrochloride → N'-Hydroxy-2-(4-methoxyphenoxy)acetimidamide
反応式
[CH3:1][O:2][C:3]1[CH:12]=[CH:11][C:6]([O:7][CH2:8][C:9]#[N:10])=[CH:5][CH:4]=1.Cl.[NH2:14][OH:15].C([O-])(=O)C.[Na+]>CO>[CH3:1][O:2][C:3]1[CH:12]=[CH:11][C:6]([O:7][CH2:8][C:9](=[N:14][OH:15])[NH2:10])=[CH:5][CH:4]=1参加物
5
実験手順
A mixture of the (4-methoxyphenoxy)acetonitrile product (5.0 g, 31 mmol) from step 1, hydroxylamine hydrochloride (4.3 g, 62 mmol) and sodium acetate (5.1 g, 62 mmol) in MeOH (100 mL) was stirred at r.t. for 2 h. The resulting mixture was filtered on Celite®, concentrated, stirred in CHCl3 for 18 h and filtered. The resulting solution was concentrated to yield (4-methoxyphenoxy)acetamide oxime as a gum.
後処理
- filtrationThe resulting mixture was filtered on Celite®
- concentrationconcentrated
- stirringstirred in CHCl3 for 18 h
- filtrationfiltered
- concentrationThe resulting solution was concentrated
出典と根拠
- ORDレコード
- ord-3bc2afdc863840a7a0ee065412c65aa4
- 出典データセット
- uspto-grants-2002_06
- 特許番号
- US06410563B1
反応ノート
読み込み中…