Sodium Hydroxide → cis-3-Azidomethylcyclopentancarboxylic acid

HRID 2187993ノート

反応式

HRID 2187993 の反応式
[N:1]([CH2:4][C@@H:5]1[CH2:9][CH2:8][C@H:7]([C:10]([O:12]C)=[O:11])[CH2:6]1)=[N+:2]=[N-:3].[OH-].[Na+]>>[N:1]([CH2:4][C@@H:5]1[CH2:9][CH2:8][C@H:7]([C:10]([OH:12])=[O:11])[CH2:6]1)=[N+:2]=[N-:3]

参加物

3

反応物 2

HCID 14798Sodium HydroxideHCID 86758274Methyl cis-3-azidomethylcyclopentancarboxylate

生成物 1

HCID 86758275cis-3-Azidomethylcyclopentancarboxylic acid収率 91%

実験手順

A mixture of methyl cis-3-azidomethylcyclopentancarboxylate (1.2 g, 6.5 mmol) and 1 N sodium hydroxide (12.0 mL, 12 mmol) was stirred at room temperature for about 8 h. The alkaline mixture was extracted with chloroform. The aqueous layer was acidified with hydrochloric acid and extracted twice with chloroform. Combined chloroform extracts from the acidic mixture were dried over sodium sulfate, filtered and concentrated to give about 1.0 g (91%) of cis-3-azidomethylcyclopentancarboxylic acid.

後処理

  1. extractionThe alkaline mixture was extracted with chloroform
  2. extractionextracted twice with chloroform
  3. dry with materialCombined chloroform extracts from the acidic mixture were dried over sodium sulfate
  4. filtrationfiltered
  5. concentrationconcentrated

出典と根拠

ORDレコード
ord-3c6b04da23ea4e3a956934210c23a89d
出典データセット
uspto-grants-2002_06
特許番号
US06410594B1

反応ノート

読み込み中…