Acetic Anhydride → rac-(1R,3S)-3-(acetamidomethyl)cyclopentane-1-carboxylic acid

HRID 2187995ノート

反応式

HRID 2187995 の反応式
[NH2:1][CH2:2][C@@H:3]1[CH2:7][CH2:6][C@H:5]([C:8]([OH:10])=[O:9])[CH2:4]1.[C:11](OC(=O)C)(=[O:13])[CH3:12]>N1C=CC=CC=1>[CH3:12][C:11]([NH:1][CH2:2][C@@H:3]1[CH2:7][CH2:6][C@H:5]([C:8]([OH:10])=[O:9])[CH2:4]1)=[O:13]

参加物

4

反応物 2

HCID 7918Acetic AnhydrideHCID 42614337rac-(1R,3S)-3-(aminomethyl)cyclopentane-1-carboxylic acid

生成物 1

HCID 12041173rac-(1R,3S)-3-(acetamidomethyl)cyclopentane-1-carboxylic acid収率 97%

試薬・触媒・溶媒 1

HCID 1049Pyridine溶媒

反応条件

温度
70 °C

実験手順

To a mixture of cis-3-aminomethylcyclopentancarboxylic acid (0.2 g, 1.4 mmol) in pyridine (about 5 mL) was added acetic anhydride (about 1 mL) and the mixture stirred at about 70° C. for about 2 h. The solvent was removed under reduced pressure, water was added several times and evaporated in vacuo. A light, viscous oil was obtained and dried in vacuo over acetone reflux to give 0.25 g (97%) of cis-3-[(methylcarbonylamino)methyl]cyclopentancarboxylic acid.

後処理

  1. customThe solvent was removed under reduced pressure, water
  2. additionwas added several times
  3. customevaporated in vacuo
  4. customA light, viscous oil was obtained
  5. dry with materialdried in vacuo over acetone
  6. temperaturereflux

出典と根拠

ORDレコード
ord-8b99720d62824a7bab8a81d775bd63cc
出典データセット
uspto-grants-2002_06
特許番号
US06410594B1

反応ノート

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