HCID 18477136、化合物 → HCID 18477085、化合物
反応式
[CH2:1]([CH2:8][NH:9][CH2:10][CH:11]1[CH2:20][CH2:19][C:18]2[C:13](=[CH:14][CH:15]=[C:16]([F:21])[CH:17]=2)[C:12]1([C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1)O)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>FC(F)(F)C(O)=O>[CH2:1]([CH2:8][NH:9][CH2:10][C:11]1[CH2:20][CH2:19][C:18]2[C:13](=[CH:14][CH:15]=[C:16]([F:21])[CH:17]=2)[C:12]=1[C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1参加物
3
実験手順
Trifluoroacetic acid (10 cm3) was added to 2-(N-benzylmethylamino)methyl-6-fluoro-1-phenyl-1,2,3,4-tetrahydronaphthalene-1-ol (1.5 g) and the resulting solution was stirred at room temperature for 2 h. The excess trifluoroacetic acid was removed under reduced pressure and the resultant brown oil was taken up into petroleum ether (b. p. 40-60° C.) and passed through a short column [basic alumina, eluting with petroleum ether (b. p. 40-60° C.)-ethyl acetate (20:1)]. The fractions containing the product were combined and the solvent removed under reduced pressure to afford the title compound (0.97 g).
後処理
- customThe excess trifluoroacetic acid was removed under reduced pressure