Bromide ion → 1-(2-Methoxyethenyl)-4-(1-methylbutyloxy)benzene

HRID 21887ノート

反応式

HRID 21887 の反応式
C([Li])CCC.[Br-].[CH3:7][CH:8]([O:12][C:13]1[CH:20]=[CH:19][C:16]([CH:17]=O)=[CH:15][CH:14]=1)[CH2:9][CH2:10][CH3:11].[O:21]1[CH2:25]CC[CH2:22]1>CCCCCC>[CH3:22][O:21][CH:25]=[CH:17][C:16]1[CH:19]=[CH:20][C:13]([O:12][CH:8]([CH3:7])[CH2:9][CH2:10][CH3:11])=[CH:14][CH:15]=1

参加物

6

反応物 4

HCID 259Bromide ionHCID 8028Tetrahydrofuran2 回HCID 199306244-(1-Methylbutyloxy)benzaldehydeHCID 178418339Butyllithium

生成物 1

HCID 537267651-(2-Methoxyethenyl)-4-(1-methylbutyloxy)benzene

試薬・触媒・溶媒 1

HCID 8058Hexane溶媒

実験手順

A solution containing butyllithium dissolved in hexane was added to a solution containing 120 g of methoxymethyltriphenylphosphoni bromide dissolved in tetrahydrofuran (THF), in an atmosphere of argon, and the mixture was stirred for one hour at room temperature. A solution of the compound (30) dissolved in THF was added thereto and stirring was continued for two hours. The reaction solution was washed with water, was dried over magnesium sulfate, and was then concentrated. The residue was purified by column chromatography to obtain 1-(2-methoxyethenyl)-4-(1-methylbutyloxy)benzene (31).

後処理

  1. additionwas added to a solution
  2. additionwas added
  3. stirringstirring
  4. waitwas continued for two hours
  5. washThe reaction solution was washed with water
  6. dry with materialwas dried over magnesium sulfate
  7. concentrationwas then concentrated
  8. customThe residue was purified by column chromatography

出典と根拠

ORDレコード
ord-c98de13488664eb499e8466680457ad6
出典データセット
uspto-grants-1995_06
特許番号
US05425897

反応ノート

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