Bromide ion → Methyl 4-(2-methoxyethenyl)benzoate

HRID 21888

反応式

HRID 21888 の反応式
C([Li])CCC.[Br-].[CH:7]([C:9]1[CH:18]=[CH:17][C:12]([C:13]([O:15][CH3:16])=[O:14])=[CH:11][CH:10]=1)=O.[O:19]1[CH2:23]CC[CH2:20]1>CCCCCC>[CH3:20][O:19][CH:23]=[CH:7][C:9]1[CH:18]=[CH:17][C:12]([C:13]([O:15][CH3:16])=[O:14])=[CH:11][CH:10]=1

参加物

6

反応物 4

HCID 259Bromide ionHCID 8028Tetrahydrofuran2 回HCID 15294Methyl 4-FormylbenzoateHCID 178418339Butyllithium

生成物 1

HCID 54136641Methyl 4-(2-methoxyethenyl)benzoate

試薬・触媒・溶媒 1

HCID 8058Hexane溶媒

実験手順

In an atmosphere of argon, a solution containing butyllithium dissolved in hexane was added to a solution containing 120 g of methoxymethyltriphenylphosphoni bromide dissolved in tetrahydrofuran (THF), and the mixture was stirred for one hour at room temperature. A solution containing 50 g of methyl 4-formylbenzoate dissolved in THF was added thereto, and stirring was continued for two hours. The reaction solution was washed with water, dried over magnesium sulfate and concentrated under reduced pressure. The residue was purified by column chromatography to obtain 47 g of methyl 4-(2-methoxyethenyl)benzoate (45).

後処理

  1. additionwas added to a solution
  2. additionwas added
  3. stirringstirring
  4. waitwas continued for two hours
  5. washThe reaction solution was washed with water
  6. dry with materialdried over magnesium sulfate
  7. concentrationconcentrated under reduced pressure
  8. customThe residue was purified by column chromatography

出典と根拠

ORDレコード
ord-30c8d4df7660407e8061edc357ed082f
出典データセット
uspto-grants-1995_06
特許番号
US05425897

関連ノート

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