Hydrazine hydrate (1:1) → 1H-Indazole-5-carbonitrile

HRID 2189732ノート

反応式

HRID 2189732 の反応式
[C:1]([C:3]1[CH:4]=[C:5](F)[CH:6]=[C:7]([CH:10]=1)[CH:8]=O)#[N:2].O.[NH2:13][NH2:14]>>[NH:13]1[C:6]2[C:7](=[CH:10][C:3]([C:1]#[N:2])=[CH:4][CH:5]=2)[CH:8]=[N:14]1

参加物

3

反応物 2

HCID 24654Hydrazine hydrate (1:1)HCID 447549173-Fluoro-5-formylbenzonitrile

生成物 1

HCID 111263841H-Indazole-5-carbonitrile

実験手順

5-Cyano-3-fluorobenzaldehyde (4 g, 26.8 mmol) was dissolved in hydrazine hydrate and stirred at room temperature for 18 hours. The solution was poured onto ice and the resultant solid was separated by filtration and then dried under vacuum at 60° C. to afford the title compound (1.27 g) as a pink solid. Further material was isolated from the aqueous layer. MS (ES): C8H5N3 requires 143; found 144 (MH+).

後処理

  1. additionThe solution was poured onto ice
  2. customthe resultant solid was separated by filtration
  3. customdried under vacuum at 60° C.

出典と根拠

ORDレコード
ord-fed1136edbaf4a77ab82c1c5925cf629
出典データセット
uspto-grants-2012_12
特許番号
US08324254B2

反応ノート

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