Hydroxyamine hydrochloride → HCID 178471847、化合物

HRID 2189779ノート

反応式

HRID 2189779 の反応式
[C:1]([C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][CH:11]=1)[N:8]([CH2:12][CH2:13][C:14]([O:16][CH2:17][CH3:18])=[O:15])[N:7]=[CH:6]2)#[N:2].C(=O)(O)[O-].[Na+].Cl.[NH2:25][OH:26]>C(O)C>[OH:26][NH:25][C:1](=[NH:2])[C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][CH:11]=1)[N:8]([CH2:12][CH2:13][C:14]([O:16][CH2:17][CH3:18])=[O:15])[N:7]=[CH:6]2

参加物

5

反応物 3

HCID 443297Hydroxyamine hydrochlorideHCID 516892Sodium BicarbonateHCID 59316705Ethyl 3-(5-cyano-1H-indazol-1-yl)propanoate

生成物 1

HCID 178471847HCID 178471847、化合物

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

反応条件

温度
50 °C

実験手順

Ethyl 3-(5-cyano-1H-indazol-1-yl)propanoate (D47) (1 g, 4.11 mmol) was dissolved in ethanol (30 ml) and sodium bicarbonate (1.73 g, 20.55 mmol) and hydroxylamine hydrochloride (571 mg, 8.22 mmol) were added. The reaction was heated at 50° C. overnight and then allowed to cool. The reaction mixture was filtered and the residue washed with ethanol. The filtrate was evaporated to dryness in vacuo and the resultant crude title compound (1.06 g) was used the subsequent reactions.

後処理

  1. temperatureto cool
  2. filtrationThe reaction mixture was filtered
  3. washthe residue washed with ethanol
  4. customThe filtrate was evaporated to dryness in vacuo

出典と根拠

ORDレコード
ord-88147cee73f647489fbcef919bffe2c4
出典データセット
uspto-grants-2012_12
特許番号
US08324254B2

反応ノート

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