Hydroxyamine hydrochloride → HCID 178471848、化合物

HRID 2189791ノート

反応式

HRID 2189791 の反応式
[C:1]([C:3]1[CH:11]=[CH:10][CH:9]=[C:8]2[C:4]=1[CH:5]=[N:6][N:7]2[CH2:12][CH2:13][C:14]([O:16][CH2:17][CH3:18])=[O:15])#[N:2].Cl.[NH2:20][OH:21].C(=O)(O)[O-].[Na+]>C(O)C>[OH:21][NH:20][C:1](=[NH:2])[C:3]1[CH:11]=[CH:10][CH:9]=[C:8]2[C:4]=1[CH:5]=[N:6][N:7]2[CH2:12][CH2:13][C:14]([O:16][CH2:17][CH3:18])=[O:15]

参加物

5

反応物 3

HCID 443297Hydroxyamine hydrochlorideHCID 516892Sodium BicarbonateHCID 59316734Ethyl 3-(4-cyano-1H-indazol-1-yl)propanoate

生成物 1

HCID 178471848HCID 178471848、化合物収率 70.4%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

Ethyl 3-(4-cyano-1H-indazol-1-yl)propanoate (D96) (0.95 g, 3.91 mmol), hydroxylamine hydrochloride (1.086 g, 15.62 mmol), and sodium bicarbonate (3.28 g, 39.1 mmol), were heated in ethanol (20 ml) at 50° C. for 3 hours. The mixture was filtered and evaporated to give the title compound (760 mg) as a white powder. MS (ES): C13H16N4O3 requires 276; found (MH+) 277.

後処理

  1. filtrationThe mixture was filtered
  2. customevaporated

出典と根拠

ORDレコード
ord-117b5d196a694df08a31c9cc25167a0f
出典データセット
uspto-grants-2012_12
特許番号
US08324254B2

反応ノート

読み込み中…