Sodium Hydroxide → Sodium 3-(5-{5-[3-chloro-4-(ethyloxy)phenyl]-1,2,4-oxadiazol-3-yl}-1H-indazol-1-yl)propanoate

HRID 2189809ノート

反応式

HRID 2189809 の反応式
[Cl:1][C:2]1[CH:3]=[C:4]([C:11]2[O:15][N:14]=[C:13]([C:16]3[CH:17]=[C:18]4[C:22](=[CH:23][CH:24]=3)[N:21]([CH2:25][CH2:26][C:27]([O:29]CC)=[O:28])[N:20]=[CH:19]4)[N:12]=2)[CH:5]=[CH:6][C:7]=1[O:8][CH2:9][CH3:10].[OH-].[Na+:33]>C(O)C>[Cl:1][C:2]1[CH:3]=[C:4]([C:11]2[O:15][N:14]=[C:13]([C:16]3[CH:17]=[C:18]4[C:22](=[CH:23][CH:24]=3)[N:21]([CH2:25][CH2:26][C:27]([O-:29])=[O:28])[N:20]=[CH:19]4)[N:12]=2)[CH:5]=[CH:6][C:7]=1[O:8][CH2:9][CH3:10].[Na+:33]

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 59316698Ethyl 3-(5-{5-[3-chloro-4-(ethyloxy)phenyl]-1,2,4-oxadiazol-3-yl}-1H-indazol-1-yl)propanoate

生成物 1

HCID 67018085Sodium 3-(5-{5-[3-chloro-4-(ethyloxy)phenyl]-1,2,4-oxadiazol-3-yl}-1H-indazol-1-yl)propanoate

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

反応条件

温度
50 °C

実験手順

Ethyl 3-(5-{5-[3-chloro-4-(ethyloxy)phenyl]-1,2,4-oxadiazol-3-yl}-1H-indazol-1-yl)propanoate (D57) (77 mg, 0.17 mmol) was suspended in 2M aq. NaOH (2 ml) and ethanol (2 ml). The mixture was heated at 50° C. until dissolved then cooled. The ethanol was removed in vacuo and the resultant solid was filtered, washed with ethanol, water and diethyl ether then dried under high vacuum to afford the title compound (63.6 mg) as a pink solid. δH (methanol-d4, 400 MHz) 1.49 (3H, t), 2.77 (2H, t), 4.25 (2H, q), 4.71 (2H, t), 7.27 (1H, d), 7.82 (1H, d), 8.09-8.25 (4H, m), 8.55 (1H, s). MS (ES): C20H1735ClN4O4 requires; 412 found (MH+) 413.

後処理

  1. dissolutionuntil dissolved
  2. temperaturethen cooled
  3. customThe ethanol was removed in vacuo
  4. filtrationthe resultant solid was filtered
  5. washwashed with ethanol, water and diethyl ether
  6. customthen dried under high vacuum

出典と根拠

ORDレコード
ord-52c92034f03f4134a1d2d6053d5421db
出典データセット
uspto-grants-2012_12
特許番号
US08324254B2

反応ノート

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