Triethylamine → HCID 67427200、化合物
反応式
[F:1][C:2]1[N:9]=[C:8](F)[C:7]([F:11])=[CH:6][C:3]=1[C:4]#[N:5].C(N(CC)CC)C.[CH3:19][C:20]1[NH:24][N:23]=[C:22]([NH2:25])[CH:21]=1>C(#N)C>[F:1][C:2]1[N:9]=[C:8]([NH:25][C:22]2[CH:21]=[C:20]([CH3:19])[NH:24][N:23]=2)[C:7]([F:11])=[CH:6][C:3]=1[C:4]#[N:5]参加物
5
反応条件
- 温度
- 0 °C
実験手順
To a solution of 2,5,6-trifluoronicotinonitrile (1.0 g, 6.3 mmol) and triethylamine (0.83 g, 8.2 mmol) in ACN (30 ml) at 0° C. was added 5-methyl-1H-pyrazol-3-amine (0.67 g, 6.9 mmol). The reaction was stirred at 0° C. for 1 hour, at which point the reaction was filtered. The resulting solid was washed with cold ACN, dried and collected to give the title compound (0.44 g, 29%). MS: Calcd.: 235. Found: [M+H]+ 236.
後処理
- filtrationwas filtered
- washThe resulting solid was washed with cold ACN
- customdried
- customcollected
出典と根拠
- ORDレコード
- ord-e66378ab6c5d46ce8c51945d95f47f84
- 出典データセット
- uspto-grants-2012_12
- 特許番号
- US08324252B2
反応ノート
読み込み中…