Sodium Cyanide → 3-Benzoylpropionitrile

HRID 2189937

反応式

HRID 2189937 の反応式
Cl[CH2:2][CH2:3][C:4]([C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1)=[O:5].C([O-])(=O)C.[K+].[C-:17]#[N:18].[Na+]>C(O)C.O>[O:5]=[C:4]([C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1)[CH2:3][CH2:2][C:17]#[N:18]

参加物

6

反応物 3

HCID 8929Sodium CyanideHCID 702953-ChloropropiophenoneHCID 517044Potassium Acetate

生成物 1

HCID 1384653-Benzoylpropionitrile収率 73%

試薬・触媒・溶媒 2

HCID 702Ethanol溶媒2 回HCID 962Water溶媒

実験手順

To a solution of 3-chloro-1-phenylpropan-1-one (5.0 g, 29.7 mmol) in hot ethanol (7 mL) was added potassium acetate (2.91 g, 29.77 mmol). After cooling to room temperature, the precipitated salt was removed via filtration. To the filtrate in a septum-sealed flask under a nitrogen bubbler was slowly added sodium cyanide (2.91 g, 59.3 mmol) as a solution in water (10 mL). After stirring at room temperature for 24 hours, ethanol (30 mL) was added, and the mixture was cooled in an ice bath. The precipitate was filtered and rinsed with ethanol to provide the product (3.42 g, 73%) as fluffy white solid.

後処理

  1. customthe precipitated salt was removed via filtration
  2. customTo the filtrate in a septum-sealed flask under a nitrogen bubbler was slowly added
  3. temperaturethe mixture was cooled in an ice bath
  4. filtrationThe precipitate was filtered
  5. washrinsed with ethanol

出典と根拠

ORDレコード
ord-2eaa63fff7b54503a240798af339fe52
出典データセット
uspto-grants-2012_12
特許番号
US08324257B2

関連ノート

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