Diisopropylethylamine → 1-{[5-Bromo-4-(3-chloro-5-fluorophenyl)furan-2-yl]carbonyl}imidazolidin-4-one

HRID 2190132ノート

反応式

HRID 2190132 の反応式
BrC1C=C(C([N:16]2C[CH2:20][NH:19][C:18](=[O:22])[CH2:17]2)=O)OC=1C1C=CC=C(Cl)C=1.[Br:23][C:24]1[O:28][C:27]([C:29]([OH:31])=O)=[CH:26][C:25]=1[C:32]1[CH:37]=[C:36]([F:38])[CH:35]=[C:34]([Cl:39])[CH:33]=1.C(N(CC)C(C)C)(C)C>>[Br:23][C:24]1[O:28][C:27]([C:29]([N:16]2[CH2:17][C:18](=[O:22])[NH:19][CH2:20]2)=[O:31])=[CH:26][C:25]=1[C:32]1[CH:37]=[C:36]([F:38])[CH:35]=[C:34]([Cl:39])[CH:33]=1

参加物

4

反応物 3

HCID 81531DiisopropylethylamineHCID 580647615-Bromo-4-(3-chloro-5-fluorophenyl)furan-2-carboxylic acidHCID 580647644-{[4-Bromo-5-(3-chlorophenyl)furan-2-yl]carbonyl}piperazin-2-one

生成物 1

HCID 580647781-{[5-Bromo-4-(3-chloro-5-fluorophenyl)furan-2-yl]carbonyl}imidazolidin-4-one

実験手順

The preparation of the title compound takes place in analogy to the synthesis of the compound from Example 27A starting with the compound from Example 23A and the compound from Example 35A. 5 equivalents of N,N-diisopropylethylamine are used. The product is precipitated by the addition of water to the reaction solution. The precipitate is collected by suction filtration, washed with tetrahydrofuran and dried under high vacuum. 587 mg (97% of theory) of the title compound are obtained.

後処理

  1. customThe product is precipitated by the addition of water to the reaction solution
  2. filtrationThe precipitate is collected by suction filtration
  3. washwashed with tetrahydrofuran
  4. customdried under high vacuum

出典と根拠

ORDレコード
ord-c78b9f9c63f1415fb41298c3e447049b
出典データセット
uspto-grants-2012_12
特許番号
US08324268B2

反応ノート

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