Hydrochloric Acid → 3-(4-aminophenoxy)-N-[4-(trifluoromethyl)phenyl]benzamide

HRID 2190420ノート

反応式

HRID 2190420 の反応式
[N+:1]([C:4]1[CH:29]=[CH:28][C:7]([O:8][C:9]2[CH:10]=[C:11]([CH:25]=[CH:26][CH:27]=2)[C:12]([NH:14][C:15]2[CH:20]=[CH:19][C:18]([C:21]([F:24])([F:23])[F:22])=[CH:17][CH:16]=2)=[O:13])=[CH:6][CH:5]=1)([O-])=O.O1CCCC1.Cl>CO.[C].[Pd]>[NH2:1][C:4]1[CH:29]=[CH:28][C:7]([O:8][C:9]2[CH:10]=[C:11]([CH:25]=[CH:26][CH:27]=2)[C:12]([NH:14][C:15]2[CH:20]=[CH:19][C:18]([C:21]([F:22])([F:23])[F:24])=[CH:17][CH:16]=2)=[O:13])=[CH:6][CH:5]=1

参加物

6

反応物 3

HCID 313Hydrochloric AcidHCID 8028TetrahydrofuranHCID 673114413-(4-nitrophenoxy)-N-[4-(trifluoromethyl)phenyl]benzamide

生成物 1

HCID 673119133-(4-aminophenoxy)-N-[4-(trifluoromethyl)phenyl]benzamide収率 86%

試薬・触媒・溶媒 2

HCID 178418390HCID 178418390、化合物触媒HCID 887Methanol溶媒

実験手順

To a solution of 3-(4-nitrophenoxy)-N-[4-(trifluoromethyl)phenyl]benzamide (6.75 g, 16.8 mmol) in methanol (20 mL)/tetrahydrofuran (10 mL) were added 10%-palladium carbon (2 g) and concentrated hydrochloric acid (1 mL), and the mixture was vigorously stirred under a hydrogen atmosphere at room temperature for 3 hr. The catalyst was filtered off through celite, the filtrate was concentrated under reduced pressure, and the obtained residue was triturated with diethyl ether to give the title compound (5.37 g, 86%) as a white solid.

後処理

  1. filtrationThe catalyst was filtered off through celite
  2. concentrationthe filtrate was concentrated under reduced pressure
  3. customthe obtained residue was triturated with diethyl ether

出典と根拠

ORDレコード
ord-9529512fc8e541ab846eb18a9c16e42a
出典データセット
uspto-grants-2012_12
特許番号
US08324395B2

反応ノート

読み込み中…