化工社化工社 化学情報印刷レポート · 研究参考用
4-N-Boc-4-N-Methyl-aminopiperidine → methyl-[5'-(5-methyl-4-phenyl-thiazol-2-ylcarbamoyl)-3,4,5,6-tetrahydro-2H-[1,2']bipyridinyl-4-yl]-carbamic acid tert-butyl ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-N-Boc-4-N-Methyl-aminopiperidine | HCID 2756806 | — |
| 反応物 | 6-chloro-N-(5-methyl-4-phenyl-1,3-thiazol-2-yl)pyridine-3-carboxamide | HCID 3379941 | — |
| 反応物 | 4-(3-trifluoromethyl-phenyl)-3,4,5,6-tetrahydro-2H-[1,2']bipyridinyl-5'-carboxylic acid (5-methyl-4-phenyl-thiazol-2-yl)-amide | HCID 59317981 | — |
| 反応物 | methyl-[5'-(5-methyl-4-phenyl-thiazol-2-ylcarbamoyl)-3,4,5,6-tetrahydro-2H-[1,2']bipyridinyl-4-yl]-carbamic acid | HCID 86641503 | — |
| 生成物 | methyl-[5'-(5-methyl-4-phenyl-thiazol-2-ylcarbamoyl)-3,4,5,6-tetrahydro-2H-[1,2']bipyridinyl-4-yl]-carbamic acid tert-butyl ester | HCID 59318109 | — |
反応手順
With a method similar to that used for the preparation of 4-(3-trifluoromethyl-phenyl)-3,4,5,6-tetrahydro-2H-[1,2′]bipyridinyl-5′-carboxylic acid (5-methyl-4-phenyl-thiazol-2-yl)-amide, methyl-[5′-(5-methyl-4-phenyl-thiazol-2-ylcarbamoyl)-3,4,5,6-tetrahydro-2H-[1,2′]bipyridinyl-4-yl]-carbamic acid tent-butyl ester was prepared from 6-chloro-N-(5-methyl-4-phenyl-thiazol-2-yl)-nicotinamide and methyl-piperidin-4-yl-carbamic acid tert-butyl ester. LCMS calcd for C27H33N5O3S (m/e) 507, obsd 508 (M+H).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08324385B2 |
| 出典データセット | uspto-grants-2012_12 |
| ORD ID | ord-5b78059953234380880b8ddc28c4d762 |
| 出典メモ | uspto-grants-2012_12 |