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Sodium Glycinate → [(4-Hydroxy-2-oxo-7-phenoxy-2H-chromene-3-carbonyl)-amino]-acetic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Sodium Glycinate | HCID 4684308 | — |
| 反応物 | 4-Hydroxy-2-oxo-7-phenoxy-2H-chromene-3-carboxylic acid ethyl ester | HCID 86649463 | — |
| 溶媒 | 1-Methoxyethanol | HCID 3015637 | — |
| 生成物 | [(4-Hydroxy-2-oxo-7-phenoxy-2H-chromene-3-carbonyl)-amino]-acetic acid | HCID 54746545 | 105.5% |
反応手順
A mixture of 4-hydroxy-2-oxo-7-phenoxy-2H-chromene-3-carboxylic acid ethyl ester (84 mg, 0.248 mmol) and sodium glycinate (121 mg, 1.24 mmol) in methoxyethanol (5 mL) was refluxed for 15 h; then cooled, the solvent was removed, the residue was redissolved in water, acidified with 2 M HCl, the precipitates were collected and freeze dried to give the desired title product (93 mg). ESI (m/z): 356 (M+H)+.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08324405B2 |
| 出典データセット | uspto-grants-2012_12 |
| ORD ID | ord-a0e542033fb84b4fa4e6abcd8255e9c0 |
| 出典メモ | uspto-grants-2012_12 |