反应详情

A mixture of 4-hydroxy-2-oxo-7-phenoxy-2H-chromene-3-carboxylic acid ethyl ester (84 mg, 0.248 mmol) and sodium glycinate (121 mg, 1.24 mmol) in methoxyethanol (5 mL) was refluxed for 15 h; then cooled, the solvent was removed, the residue was redissolved in water, acidified with 2 M HCl, the precipitates were collected and freeze dried to give the desired title product (93 mg). ESI (m/z): 356 (M+H)+.

1. temperaturewas refluxed for 15 h
2. temperaturethen cooled
3. customthe solvent was removed
4. dissolutionthe residue was redissolved in water
5. customthe precipitates were collected
6. customfreeze dried