Methyl iodide → (S)-1-(3-methoxyphenyl)-N-methyl-N-((S)-1-phenylethyl)ethanamine

反応式

[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C@@H:9]([NH:11][C@H:12]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[CH3:13])[CH3:10])[CH:6]=[CH:7][CH:8]=1.CI.S(OC)(O[CH3:26])(=O)=O>>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C@@H:9]([N:11]([CH3:26])[C@H:12]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[CH3:13])[CH3:10])[CH:6]=[CH:7][CH:8]=1

参加物

反応物 3

HCID 6328Methyl iodide

HCID 6497Dimethyl Sulfate

HCID 13234525(S)-1-(3-methoxy phenyl)-N-((S)-1-phenylethyl)ethylamine

生成物 1

HCID 42604949(S)-1-(3-methoxyphenyl)-N-methyl-N-((S)-1-phenylethyl)ethanamine

実験手順

In another embodiment, the second approach: The methylation reaction is carried out using (S)-1-(3-methoxy phenyl)-N—((S)-1-phenylethyl)ethylamine as a raw material, and methyl iodide or dimethyl sulfate as a methylation agent, so as to obtain (S)-1-(3-methoxyphenyl)-N-methyl-N—[(S)-1-phenylethyl]ethylamine. Methyl iodide or dimethyl sulfate are conventional methylation agents, and the method is common in the art. See OS, CV4, 836 (1963); OS, CV3, 753 (1955), which are incorporated herewith by reference in their entireties.