Hydrogen Peroxide → HCID 136351465、化合物

HRID 2191050ノート

反応式

HRID 2191050 の反応式
[NH2:1][C:2]1[NH:3][C:4](=[O:31])[C:5]2[N:6]=[CH:7][N:8]([C@@H:11]3[O:15][C@H:14]([CH2:16][CH:17]([P:25](=[O:28])([OH:27])[OH:26])[S:18][C:19]4[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=4)[C@@H:13]([F:29])[C@H:12]3[OH:30])[C:9]=2[N:10]=1.OO.S([O-])([O-])=[O:35].[Na+].[Na+]>O>[NH2:1][C:2]1[NH:3][C:4](=[O:31])[C:5]2[N:6]=[CH:7][N:8]([C@@H:11]3[O:15][C@H:14]([CH2:16][CH:17]([P:25](=[O:27])([OH:26])[OH:28])[S:18]([C:19]4[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=4)=[O:35])[C@@H:13]([F:29])[C@H:12]3[OH:30])[C:9]=2[N:10]=1

参加物

5

反応物 3

HCID 784Hydrogen PeroxideHCID 24437Sodium SulfiteHCID 136173376HCID 136173376、化合物

生成物 1

HCID 136351465HCID 136351465、化合物収率 77%

試薬・触媒・溶媒 1

HCID 962Water溶媒

反応条件

温度
90 °C

実験手順

Compound 35.17 (15 mg, 0.032 mmol) was suspended in 3 mL water, and treated with 30% hydrogen peroxide (100 mL). The mixture was heated to 90° C. for 3 h and sodium sulfite (113 mg, 0.9 mmol) was added to quench the peroxide. The solvent was removed under reduced pressure and the residue was subjected to a reverse phase HPLC to give compound 35.18 (12 mg, 77% yield).

後処理

  1. customto quench the peroxide
  2. customThe solvent was removed under reduced pressure

出典と根拠

ORDレコード
ord-67811de63c014379931a608fd2577b90
出典データセット
uspto-grants-2012_12
特許番号
US08324179B2

反応ノート

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