Trifluoroacetic acid → 4-(Benzothiophene-3-carboxamido)-2-(4-fluoroanilino)benzoic acid

HRID 2191700ノート

反応式

HRID 2191700 の反応式
FC(F)(F)C(O)=O.[S:8]1[C:12]2[CH:13]=[CH:14][CH:15]=[CH:16][C:11]=2[C:10]([C:17]([NH:19][C:20]2[CH:32]=[CH:31][C:23]([C:24]([O:26]C(C)(C)C)=[O:25])=[C:22]([NH:33][C:34]3[CH:39]=[CH:38][C:37]([F:40])=[CH:36][CH:35]=3)[CH:21]=2)=[O:18])=[CH:9]1>>[S:8]1[C:12]2[CH:13]=[CH:14][CH:15]=[CH:16][C:11]=2[C:10]([C:17]([NH:19][C:20]2[CH:32]=[CH:31][C:23]([C:24]([OH:26])=[O:25])=[C:22]([NH:33][C:34]3[CH:35]=[CH:36][C:37]([F:40])=[CH:38][CH:39]=3)[CH:21]=2)=[O:18])=[CH:9]1

参加物

3

反応物 2

HCID 6422Trifluoroacetic acidHCID 68959063Tert-butyl 4-(benzothiophene-3-carboxamido)-2-(4-fluoroanilino)benzoate

生成物 1

HCID 576679764-(Benzothiophene-3-carboxamido)-2-(4-fluoroanilino)benzoic acid

実験手順

Trifluoroacetic acid 5 mL was added to the obtained tert-butyl 4-(benzothiophene-3-carboxamido)-2-(4-fluoroanilino)benzoate, and it was stirred at room temperature for 1 hour. The solvent was removed under reduced pressure,diisopropyl ether was added to the obtained residue, and solid matter was filtrated to give 4-(benzothiophene-3-carboxamido)-2-(4-fluoroanilino)benzoic acid 24 mg of white solid.

後処理

  1. customThe solvent was removed under reduced pressure,diisopropyl ether
  2. additionwas added to the obtained residue, and solid matter
  3. filtrationwas filtrated

出典と根拠

ORDレコード
ord-af9d798f9cda474196b97b1ec0fd66be
出典データセット
uspto-grants-2012_12
特許番号
US08327467B2

反応ノート

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