Acetamide → Methyl 6-benzoyloxyhexanoate
反応式
[C:1]([O:9][CH2:10][CH2:11][CH2:12][CH2:13][CH:14](Br)[C:15]([O:17][CH3:18])=[O:16])(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[F-:20].[K+].C(N)(=O)C>>[C:1]([O:9][CH2:10][CH2:11][CH2:12][CH2:13][CH:14]([F:20])[C:15]([O:17][CH3:18])=[O:16])(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:1]([O:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][C:15]([O:17][CH3:18])=[O:16])(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1参加物
5
反応条件
- 温度
- 105 °C
実験手順
A mixture of methyl 6-benzoyloxy-2(RS)-bromo-hexanoate (e) (14.02 g), potassium fluoride (12.59 g) and acetamide (12.3 g) was stirred at 105° C. for 6 hours. The crude product obtained by treating in the conventional manner was subjected to silica gel chromatography to give the title compound (f) and methyl 6-benzoyloxyhexanoate (g) (3.11 g, yield: 29%).