Trifluoroacetic acid → HCID 57667846、化合物

HRID 2191818ノート

反応式

HRID 2191818 の反応式
FC(F)(F)C(O)=O.C(OC([O:15][C:16]1[CH:17]=[C:18]([C:22]2[CH:34]=[CH:33][C:25]([C:26]([O:28]C(C)(C)C)=[O:27])=[C:24]([NH:35][C:36]3[CH:41]=[CH:40][CH:39]=[C:38]([OH:42])[CH:37]=3)[CH:23]=2)[CH:19]=[CH:20][CH:21]=1)=O)(C)(C)C>>[OH:15][C:16]1[CH:17]=[C:18]([C:22]2[CH:34]=[CH:33][C:25]([C:26]([OH:28])=[O:27])=[C:24]([NH:35][C:36]3[CH:41]=[CH:40][CH:39]=[C:38]([OH:42])[CH:37]=3)[CH:23]=2)[CH:19]=[CH:20][CH:21]=1

参加物

3

反応物 2

HCID 6422Trifluoroacetic acidHCID 68963254HCID 68963254、化合物

生成物 1

HCID 57667846HCID 57667846、化合物

実験手順

Trifluoroacetic acid 5.0 mL was added to the obtained tert-butyl 4-(3-(tert-butoxycarbonyl)oxyphenyl)-2-((3-hydroxyphenyl)amino)benzoate, and it was stirred at room temperature for 3 hours. The solvent was removed under reduced pressure, hexane and diisopropyl ether were added to the obtained residue, and solid matter was filtrated to give 4-(3-hydroxyphenyl)-2-((3-hydroxyphenyl)amino)benzoic acid 10 mg of a yellow solid.

後処理

  1. customThe solvent was removed under reduced pressure, hexane and diisopropyl ether
  2. additionwere added to the obtained residue, and solid matter
  3. filtrationwas filtrated

出典と根拠

ORDレコード
ord-e1be98da4bf4461f8d2f72eaa4f7edd0
出典データセット
uspto-grants-2012_12
特許番号
US08327467B2

反応ノート

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