Sodium Hydroxide → HCID 59740981、化合物
反応式
[F:1][C:2]1[CH:3]=[C:4]([NH:30]C(=O)C)[CH:5]=[C:6]([F:29])[C:7]=1[O:8][C:9]1[CH:14]=[CH:13][N:12]=[C:11]2[N:15](S(C3C=CC(C)=CC=3)(=O)=O)[CH:16]=[C:17]([CH3:18])[C:10]=12.[OH-].[Na+]>C(O)C>[F:29][C:6]1[CH:5]=[C:4]([CH:3]=[C:2]([F:1])[C:7]=1[O:8][C:9]1[CH:14]=[CH:13][N:12]=[C:11]2[NH:15][CH:16]=[C:17]([CH3:18])[C:10]=12)[NH2:30]参加物
4
反応条件
- 温度
- 90 °C
実験手順
690 mg (1.46 mmol) of N-[3,5-difluoro-4-({3-methyl-1-[(4-methylphenyl)sulfonyl]-1H-pyrrolo[2,3-b]pyridin-4-yl}oxy)phenyl]acetamide are dissolved in 25 ml of ethanol. 12.5 ml of 20% strength aqueous sodium hydroxide solution are added, and the reaction mixture is heated at 90° C. for 4.5 hours. The reaction solution is partitioned between ethyl acetate and water. The aqueous phase is extracted with ethyl acetate. The combined organic phases are dried over magnesium sulfate and the solvent is removed under reduced pressure. The product is reacted without further purification.