Sodium Hydroxide → 3-Fluoro-4-{[3-(2-methoxyethyl)-1H-pyrrolo[2,3-b]pyridin-4-yl]oxy}aniline

HRID 2192174ノート

反応式

HRID 2192174 の反応式
[F:1][C:2]1[CH:3]=[C:4]([NH:22]C(=O)C)[CH:5]=[CH:6][C:7]=1[O:8][C:9]1[CH:14]=[CH:13][N:12]=[C:11]2[NH:15][CH:16]=[C:17]([CH2:18][CH2:19][O:20][CH3:21])[C:10]=12.[OH-].[Na+]>C(O)C>[F:1][C:2]1[CH:3]=[C:4]([CH:5]=[CH:6][C:7]=1[O:8][C:9]1[CH:14]=[CH:13][N:12]=[C:11]2[NH:15][CH:16]=[C:17]([CH2:18][CH2:19][O:20][CH3:21])[C:10]=12)[NH2:22]

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 59741010N-(3-Fluoro-4-{[3-(2-methoxyethyl)-1H-pyrrolo[2,3-b]pyridin-4-yl]oxy}phenyl)acetamide

生成物 1

HCID 597410123-Fluoro-4-{[3-(2-methoxyethyl)-1H-pyrrolo[2,3-b]pyridin-4-yl]oxy}aniline

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

反応条件

温度
90 °C

実験手順

63 mg (0.18 mmol) of N-(3-fluoro-4-{[3-(2-methoxyethyl)-1H-pyrrolo[2,3-b]pyridin-4-yl]oxy}phenyl)acetamide are dissolved in 5 ml of ethanol. 2 ml of 20% strength aqueous sodium hydroxide solution are added, and the mixture is stirred at 90° C. overnight. The reaction mixture is then partitioned between ethyl acetate and 1N aqueous sodium hydroxide solution. The aqueous solution is extracted with ethyl acetate and the combined organic phases are washed with 1N aqueous sodium hydroxide solution. The organic phases are dried over magnesium sulfate and the solvent is removed under reduced pressure. The product is reacted further without purification.

後処理

  1. customThe reaction mixture is then partitioned between ethyl acetate and 1N aqueous sodium hydroxide solution
  2. extractionThe aqueous solution is extracted with ethyl acetate
  3. washthe combined organic phases are washed with 1N aqueous sodium hydroxide solution
  4. dry with materialThe organic phases are dried over magnesium sulfate
  5. customthe solvent is removed under reduced pressure
  6. customThe product is reacted further without purification

出典と根拠

ORDレコード
ord-50bf8ad04cd8421a9686db483d298bdc
出典データセット
uspto-grants-2012_12
特許番号
US08329716B2

反応ノート

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