Sodium Hydroxide → 4-[(3-cyclopropyl-1H-pyrrolo[2,3-b]pyridin-4-yl)oxy]-3,5-difluoroaniline

HRID 2192177ノート

反応式

HRID 2192177 の反応式
[CH:1]1([C:4]2[C:12]3[C:7](=[N:8][CH:9]=[CH:10][C:11]=3[O:13][C:14]3[C:19]([F:20])=[CH:18][C:17]([NH:21]C(=O)C)=[CH:16][C:15]=3[F:25])[N:6](S(C3C=CC(C)=CC=3)(=O)=O)[CH:5]=2)[CH2:3][CH2:2]1.[OH-].[Na+]>C(O)C>[CH:1]1([C:4]2[C:12]3[C:7](=[N:8][CH:9]=[CH:10][C:11]=3[O:13][C:14]3[C:15]([F:25])=[CH:16][C:17]([NH2:21])=[CH:18][C:19]=3[F:20])[NH:6][CH:5]=2)[CH2:3][CH2:2]1

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 59741001N-[4-({3-Cyclopropyl-1-[(4-methylphenyl)sulfonyl]-1H-pyrrolo[2,3-b]pyridin-4-yl}oxy)-3,5-difluorophenyl]acetamide

生成物 1

HCID 597409994-[(3-cyclopropyl-1H-pyrrolo[2,3-b]pyridin-4-yl)oxy]-3,5-difluoroaniline

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

反応条件

温度
90 °C

実験手順

624 mg (1.25 mmol) of N-[4-({3-cyclopropyl-1-[(4-methylphenyl)sulfonyl]-1H-pyrrolo[2,3-b]-pyridin-4-yl}oxy)-3,5-difluorophenyl]acetamide are dissolved in 17 ml of ethanol. 10 ml of semiconcentrated aqueous sodium hydroxide solution are added, and the reaction mixture is stirred at 90° C. for 15 h. The reaction mixture is partitioned between ethyl acetate and water. The organic phase is washed twice with water, dried over sodium sulfate and concentrated under reduced pressure. This gives a crystalline residue.

後処理

  1. customThe reaction mixture is partitioned between ethyl acetate and water
  2. washThe organic phase is washed twice with water
  3. dry with materialdried over sodium sulfate
  4. concentrationconcentrated under reduced pressure
  5. customThis gives a crystalline residue

出典と根拠

ORDレコード
ord-e1868c3891304200889780930c3dc0bd
出典データセット
uspto-grants-2012_12
特許番号
US08329716B2

反応ノート

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